globeandmail.com: Deactivating brain area can stop addictions cold

globeandmail.com: Deactivating brain area can stop addictions cold: "Deactivating brain area can stop addictions cold Reuters October 25, 2007 at 10:30 PM EDT SANTIAGO — Chilean scientists have made a discovery in the brains of rats that they say may help treat drug addiction and ease the side effects of some medications. Researchers at the Pontifical Catholic University in Santiago say they identified a region of the brain, the insular cortex, that plays an important role in drug craving. Tests on amphetamine-addicted laboratory rats showed that when the insular cortex was deactivated by injecting a drug that halted brain cell activity, the rats showed no signs of addiction. When the insular cortex was reactivated, the rats again showed signs of craving amphetamines, according to the research to be published in Friday's edition of the journal Science. '(This) indicates to us that this region of the brain processes information about the physiological states of the body and may guide behaviour,' said Fernando Torrealba, one of the researchers. In a second experiment, Dr. Torrealba's team injected rats with lithium, a drug used to treat mental illness that has side effects including malaise and intestinal pain. When the insular cortex was switched off, the rats showed no sign of "